Endocrine Abstracts

KML001 is an orally bioavailable and water soluble trivalent arsenic compound having anti-cancer activity via controlling the numerous signaling pathways including phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways. PI3K/Akt and ERK signaling pathways are overactivated in adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. In this study, we evaluated the effects of KML001 on cell viability, cell cycle, apoptosis,...

Hirsutism, excessive terminal hair growth in a male-like pattern as a marker of hyperandrogenism, affects 5–10% of reproductive-age women worldwide. The frequency of hirsutism seems to decrease in Asians and the lower cut-off modified hirsutism score is suggested. We performed the study to estimate the frequency, bio-metabolic characteristics, correlates and determinants of hirsutism in reproductive aged Korean women. A total of 2682 female volunteers of reproductive age ...

Introduction: Although menstrual irregularity, including oligomenorrhea (OM), is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with OM is unclear. We evaluated whether a longer menstrual cycle length is associated with less favorable metabolic features in young women.Methods/design: A total of 1296 young women (aged 15–39 years old) with ...

The measurement of androgens is critical for the diagnosis of polycystic ovary syndrome (PCOS) but it has been difficult based on poor specificity and sensitivity of assays in the female range. The direct total androgen activity can be measured with dihydrotestosterone equivalent concentration (DEQ) using chemically activated luciferase gene expression (CALUX) bioassays. The aim of the study is to determine whether DEQ levels can be the index for hyperandrogenemia to be requir...

Background: The risk of iodine-induced thyrotoxicosis is increased in patients with Graves’ disease and multi nodular goiter with thyroid autonomy. At same time, hypothyroidism can develop after iodine exposure in patients with Hashimoto’s thyroiditis. But, there are no studies about the influence of iodine containing contrast media on thyroid function in iodine excessive area. This study was done to evaluate the changes of thyroid function after coronary angiography...

Background: Polycystic ovary syndrome (PCOS) constitutes the most common endocrine disorder in women of reproductive age. Recently, the potential influence of endocrine disrupting chemicals (EDCs) on the development of PCOS has been suggested. The aim of the present study is to determine whether dihydrotestosterone equivalent concentration (DEQ) representing total androgenic activities including androgen derivatives from EDCs measured by chemically activated luciferase gene ex...

The prevalence of polycystic ovary syndrome (PCOS) is generally estimated at 5–7% in women of reproductive age. But studies regarding the prevalence of PCOS have largely been confined to non-Asians. We aimed to estimate prevalence and phenotype of PCOS in Korean women. Cross sectional study was done between November 2008 and May 2009. A questionnaire based on menstrual history and clinical manifestations of hyperandrogenism was utilized to find out ‘probable cases&#1...

Somatostatin analogues (SSA) are widely used for the treatment of patients with acromegaly, and the responses are variable. We investigated the possible predictive factors of the response to SSA therapy in Korean acromegalic patients. Twenty-eight patients were retrospectively analysed, who were treated by surgery and adjunctively SSA. Somatostatin suppression tests (SST, hourly GH measurements for 3 h following 100 μg somatostatin injection) were done before SSAs were gi...